Blar i NTNU Open på forfatter "Løvland, Sigrid Sløgedal"
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Lipase Catalyzed Synthesis of Enantiopure Precursors and Derivatives for β-Blockers Practolol, Pindolol and Carteolol
Gundersen, Morten Andre; Austli, Guro Buaas; Løvland, Sigrid Sløgedal; Hansen, Mari Bergan; Rødseth, Mari; Jacobsen, Elisabeth Egholm (Peer reviewed; Journal article, 2021)Sustainable methods for producing enantiopure drugs have been developed. Chlorohydrins as building blocks for several β-blockers have been synthesized in high enantiomeric purity by chemo-enzymatic methods. The yield of ... -
Synthesis of building blocks for (S)-pindolol and vitamin K2 by use of lipase catalysis
Løvland, Sigrid Sløgedal (Master thesis, 2018)The objective of this thesis has been to synthesize an enantiopure building block of beta-blocker (S)-pindolol. This has been attempted by organic synthesis followed by lipase catalysis using candida antarctica lipase B ...